IL-6 Receptor Antikörper

Produktnummer ABIN1383676

Dieser Maus Monoklonal Antikörper erkennt spezifisch IL-6 Receptor in ELISA und FACS. Er zeigt eine Reaktivität gegenüber Human und wurde in 5+ Publikationen erwähnt.

Kurzübersicht für IL-6 Receptor Antikörper (ABIN1383676)

Target: IL-6 Receptor (IL6R) (Interleukin 6 Receptor (IL6R))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IL-6 Receptor Antikörper ist unkonjugiert

Applikation: ELISA, Flow Cytometry (FACS)

Klon: B-N12

Produktdetails anti-IL-6 Receptor Antikörper

Spezifität: Recognises the Interleukin-6 Ra subunit, IL-6 Ra, IL-6 R, a 80 kDa protein

Aufreinigung: Ion exchange chromatography

Sterilität: 0.22 μm filtered

Immunogen: gp80 transfected CHO cell line,Myeloma X63/AG.8653 x Balb/c spleen cells

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Phosphate-buffered saline. Sterile-filtered through 0.22 μm. Carrier and preservative free

Konservierungsmittel: Without preservative

Lagerung: 4 °C

Informationen zur Lagerung: Stable at +2-8°C for 12 months. For longer storage freeze aliquots.

Referenzen für anti-IL-6 Receptor Antikörper (ABIN1383676)

Labbozzetta, Notarbartolo, Poma, Giannitrapani, Cervello, Montalto, DAlessandro: "Significance of autologous interleukin-6 production in the HA22T/VGH cell model of hepatocellular carcinoma." in: Annals of the New York Academy of Sciences, Vol. 1089, pp. 268-75, (2007) (PubMed).

Kube, Holtick, Vockerodt, Ahmadi, Haier, Behrmann, Heinrich, Diehl, Tesch: "STAT3 is constitutively activated in Hodgkin cell lines." in: Blood, Vol. 98, Issue 3, pp. 762-70, (2001) (PubMed).

Lebeau, Montero Julian, Wijdenes, Müller-Newen, Dahmen, Chérel, Heinrich, Brailly, Hallet, Godard, Minvielle, Jacques: "Reconstitution of two isoforms of the human interleukin-11 receptor and comparison of their functional properties." in: FEBS letters, Vol. 407, Issue 2, pp. 141-7, (1997) (PubMed).

Müller-Newen, Köhne, Keul, Hemmann, Müller-Esterl, Wijdenes, Brakenhoff, Hart, Heinrich: "Purification and characterization of the soluble interleukin-6 receptor from human plasma and identification of an isoform generated through alternative splicing." in: European journal of biochemistry / FEBS, Vol. 236, Issue 3, pp. 837-42, (1996) (PubMed).

Mouthon, Freund, Titeux, Katz, Guichard, Breton-Gorius, Vainchenker: "Growth and differentiation of the human megakaryoblastic cell line (ELF-153): a model for early stages of megakaryocytopoiesis." in: Blood, Vol. 84, Issue 4, pp. 1085-97, (1994) (PubMed).

Details zu IL-6 Receptor

Target: IL-6 Receptor (IL6R) (Interleukin 6 Receptor (IL6R))

Andere Bezeichnung: CD126

Hintergrund: IL-6R / gp80

Molekulargewicht: 80 kDa

Pathways: JAK-STAT Signalweg, Autophagie, Growth Factor Binding, Cancer Immune Checkpoints